AskDefine | Define dicer

Dictionary Definition

dicer n : a mechanical device used for dicing food

Extensive Definition

thumb|200px|One molecule of the Dicer protein from [[Giardia intestinalis, which catalyzes the cleavage of dsRNA to siRNAs. The RNase III domains are colored green, the PAZ domain yellow, the platform domain red, and the connector helix blue. The distance between the RNase III and PAZ domains, determined by the length and angle of the connector helix, has been suggested as the determinant for the length of siRNA molecules produced by a given Dicer variant.]]
Dicer is a ribonuclease in the RNase III family that cleaves double-stranded RNA (dsRNA) and pre-microRNA (miRNA) into short double-stranded RNA fragments called small interfering RNA (siRNA) about 20-25 nucleotides long, usually with a two-base overhang on the 3' end. Dicer contains two RNase III domains and one PAZ domain; the distance between these two regions of the molecule is determined by the length and angle of the connector helix and determines the length of the siRNAs it produces. The human version of this gene is DICER1.


Dicer was given its name by Emily Bernstein, a graduate student in Greg Hannon's group at the Cold Spring Harbor Laboratory, who first demonstrated the enzyme's dsRNA "dicing" activity.


External links

dicer in German: Dicer
dicer in Spanish: Dicer
dicer in French: Dicer
dicer in Italian: Ribonucleasi III
dicer in Urdu: طاسہ
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